List of Dissertation Abstracts from previous PhD Students
My research objective is to detecting molecular interactions and their dynamics under the scope of biological systems through computational and statistical analyses on available large scale qualitative and quantitative information. With the fast developments of high-throughput technologies, such as the ChIP-chip and the next generation sequencing, this thesis provides a computational modeling framework to predict significant molecular interactions involved in signaling pathways and gene regulatory networks through dynamical system models (DSM). Models, especially mathematical models, are widely used in practice, allowing one to understand the properties and performances of any system, such as models of cars or flights. A DSM consisted of a set of ordinary differential equations (ODE), each of which models expression changing rates of a molecule in a biological system. Each variable in a DSM represent an molecule in a biological system, thus dynamics of all interested molecule are able to be captured. Depends on available qualitative and quantitative information, the proposed framework analyze them in three levels: DSM reconstruction, DSM comparison and DSM exploration.
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