Computational biology has been a rapidly developing field in the past decade.  It has become an essential component of current biomedical research. Computational biology is a very broad area that is closely associated with new techniques in molecular biology, physics, chemistry, mathematics, and especially computational science.  The emphasis of the talk will be on constructing 3-dimensional structures of protein molecules using electron cryomicroscopy and image processing, a subarea of computational biology.  Examples of targeting biological questions relating to molecular structure using a combination of techniques in genetic engineering, virology, physics, image processing, 3-dimensional reconstruction, and visualization will be discussed.