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• Multi-scale modelling of spatial and spatio-temporal patterns in biological developments.

  We study the dynamics of the developmental patterns on a variety of domains, from tissue formation to animal coats. To be more specific, we model the developmental patterns in an integrated environment of molecular-level regulatory interactions and cellular-level activities, including mitosis, cell differentiation, cell migration and apoptosis. Our latest biological validation is on Drosophila's eye formation.

  Student:
  • Hien Nguyen
  Publications:
  • Integrated Cellular and Gene Interaction Model for Cell Migration in Embryonic Development, Proceedings of IDASB (workshop on Integrative Data Analysis in Systems Biology at BIBM2010)
  • Integrated cellular and gene interaction modeling of pattern formation in Interational Journal of Computational Biology and Drug Design vol. 4, no. 4, pages 361-372

• A computational modeling framework for gene regulatory networks based on insufficient data

  Deals with developing statistical modeling on gene regulatory networks

  Students:
  • Yang Zhang
  • Zhengyu Ouyang
  Publications:
  • Comparative Generalized Logic Modeling Reveals Differential Gene Interactions during Cell Cycle Exit in Drosophila Wing Development
  • Comparative Identification of Differential Interactions from Trajectories of Dynamic Biological Networks

• CDAO-Store

  CDAO-store is a repository providing a rich set of API's for querying and visualizing phyloinformatics data.

  Students:
  • Brandon Chisham
  • Trung Le
  • Ben Wright
  Publications/Conferences:
  • iEvoBio2010 [Abstract]
  • CDAO-Store: Ontology-driven Data Integration for Phylogenetic Analysis in BMC Bioinformatics 2011, 12:98
  Link: Homepage | Repository

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